منابع مشابه
The particle has landed--characterizing the fate of inhaled pharmaceuticals.
Although there is a modest body of literature on the absorption of inhaled pharmaceuticals by normal lungs and some limited information from diseased lungs, there is still a surprising lack of mechanistic knowledge about the details of the processes involved. Where are molecules absorbed, what mechanisms are involved, how well are different lung regions penetrated, what are the determinants of ...
متن کاملCharacterizing Cell-Decomposable Metrics
To a finite metric space (X, d) one can associate the so called tight-span T (d) of d, that is, a canonical metric space (T (d), d∞) into which (X, d) isometrically embeds and which may be thought of as the abstract convex hull of (X, d). Amongst other applications, the tight-span of a finite metric space has been used to decompose and classify finite metrics, to solve instances of the server a...
متن کاملEditorial: Cell Fate
The complexity and plasticity of cell fate determination has intrigued cell and developmental biologists for decades. Cellular differentiation is the acquisition of specialized characteristics; which is intimately associated with changes in gene expression, alterations of chromatin, and changes in nuclear architecture. Differentiating tissues exhibit a progressive restriction of cellular plasti...
متن کاملHermaphrodite cell-fate specification.
There are two sexes in C. elegans, hermaphrodite and male. While there are many sex-specific differences between males and hermaphrodites that affect most tissues, the basic body plan and many of its structures are identical. However, most structures required for mating or reproduction are sexually dimorphic and are generated by sex-specific cell lineages. Thus to understand cell fate specifica...
متن کاملStochasticity and cell fate.
Fundamental to living cells is the capacity to differentiate into subtypes with specialized attributes. Understanding the way cells acquire their fates is a major challenge in developmental biology. How cells adopt a particular fate is usually thought of as being deterministic, and in the large majority of cases it is. That is, cells acquire their fate by virtue of their lineage or their proxim...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2014
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg3847